Factors associated with the lifestyle of state basic education teachers of state during the pandemic.

OBJECTIVE: To analyze the prevalence and factors associated with the lifestyle profile of public basic education teachers in Minas Gerais during the COVID-19 pandemic. METHOD: Epidemiological websurvey carried out with public basic education teachers in Minas Gerais. Data collection took place from August to September2020 via digital form. Anthropometric, sociodemographic, work, and lifestyle characteristics were evaluated. Poisson Regression was used. RESULTS: 15,641 teachers participated and 31.1% had inadequate health habits. There was a higher prevalence among men (PR=1.38; 95%CI:1.31;1.45), older age (PR=1.20; 95%CI: 1.07;1.34), greater weekly workload (RP=1.10; 95%CI:1.03;1.17) and those dissatisfied with work (RP=1.21; 95%CI:1.15;1.27). As a protective factor, professors with longer teaching experience (RP=0.92; 95%CI:0.87;0.98) and those hired or appointed (PR=0.89; 95%CI:0.85) ;0.94). CONCLUSION: Lifestyle inadequacy was found among older male teachers, with longer working hours and job dissatisfaction.

Physical Activity among Elderly Teachers Working in Basic Education Schools.

This study aimed to assess the levels of physical activity (PA) among elderly teachers. It was an epidemiological, cross-sectional, and analytical web survey conducted with teachers working in public basic education schools. Data collection took place between October and December 2021 through an online form. The dependent variable was physical activity practice, classifying teachers as either physically active or inactive. Descriptive, bivariate, and multiple analyses were performed using Poisson Regression with robust variance. A total of 1907 teachers participated in the study, of whom 5.6% were elderly, ranging in age from 60 to 72 years. Regarding PA practice, elderly teachers were found to be more physically inactive compared with adult teachers (PR = 1.18; 95% CI = 1.04; 1.34). Conclusion: A statistically significant difference in PA practice was observed between adult and elderly teachers, indicating that elderly teachers are more physically inactive.

Interrelationships between dissatisfaction with teaching work and depressive symptoms: Structural equation modelling. / Inter-relações entre insatisfação com o trabalho docente e sintomas depressivos: modelagem com equações estruturais.

The objective of this article is to evaluate the interrelationships of factors associated with depressive symptoms (DS) in teachers, considering dissatisfaction with the teaching job as a possible mediator. This was a cross-sectional study using data from 700 teachers from the public school system of a Brazilian municipality. The outcome of interest was DS, as assessed using the Beck Depression Inventory (BDI). Direct and indirect interrelationships between the outcome and dissatisfaction with work, age, income, lifestyle and adiposity were tested. These variables composed the operational model tested by structural equation modelling. Older age (ß=0.12) and greater dissatisfaction with work (ß=0.12) were directly associated with DS. A more favourable lifestyle (ß=-0.60) and adiposity (ß=-0.10) were associated with a lower occurrence of DS. The variables lifestyle (ß=-0.06) and adiposity (ß=-0.02) also had negative indirect effects on DS, mediated by job dissatisfaction. The structural equation model tested identified interrelationships that influenced DS. Dissatisfaction with teaching work was associated with DS and mediated the relationship of other factors with such symptoms.

O objetivo deste artigo é avaliar inter-relações de fatores associados a sintomas depressivos (SD) em professores, considerando a insatisfação com o trabalho docente como possível mediador. Estudo transversal utilizando dados de 700 professores da rede pública de ensino de um município brasileiro. O desfecho de interesse foi SD aferido pelo Inventário de Depressão de Beck (BDI). Foram testadas inter-relações diretas e indiretas entre o desfecho e insatisfação com o trabalho, idade, renda, estilo de vida e adiposidade. Essas variáveis compuseram modelo operacional testado por meio de modelagem de equações estruturais. A maior idade (ß=0,12) e a maior insatisfação com o trabalho (ß=0,12) associaram-se diretamente aos SD. Já o estilo de vida mais favorável (ß=-0,60) e a adiposidade (ß=-0,10), associaram-se a menor ocorrência de SD. As variáveis estilo de vida (ß=-0,06) e adiposidade (ß=-0,02) também apresentaram efeitos indiretos negativos nos SD, mediados pela insatisfação com o trabalho. O modelo de equação estrutural testado identificou inter-relações que influenciaram os SD. A insatisfação com o trabalho docente associou-se aos SD e mediou a relação de outros fatores sobre tais sintomas.

Inter-relações entre insatisfação com o trabalho docente e sintomas depressivos: modelagem com equações estruturais / Interrelationships between dissatisfaction with teaching work and depressive symptoms: Structural equation modelling

Resumo O objetivo deste artigo é avaliar inter-relações de fatores associados a sintomas depressivos (SD) em professores, considerando a insatisfação com o trabalho docente como possível mediador. Estudo transversal utilizando dados de 700 professores da rede pública de ensino de um município brasileiro. O desfecho de interesse foi SD aferido pelo Inventário de Depressão de Beck (BDI). Foram testadas inter-relações diretas e indiretas entre o desfecho e insatisfação com o trabalho, idade, renda, estilo de vida e adiposidade. Essas variáveis compuseram modelo operacional testado por meio de modelagem de equações estruturais. A maior idade (β=0,12) e a maior insatisfação com o trabalho (β=0,12) associaram-se diretamente aos SD. Já o estilo de vida mais favorável (β=-0,60) e a adiposidade (β=-0,10), associaram-se a menor ocorrência de SD. As variáveis estilo de vida (β=-0,06) e adiposidade (β=-0,02) também apresentaram efeitos indiretos negativos nos SD, mediados pela insatisfação com o trabalho. O modelo de equação estrutural testado identificou inter-relações que influenciaram os SD. A insatisfação com o trabalho docente associou-se aos SD e mediou a relação de outros fatores sobre tais sintomas.

Abstract The objective of this article is to evaluate the interrelationships of factors associated with depressive symptoms (DS) in teachers, considering dissatisfaction with the teaching job as a possible mediator. This was a cross-sectional study using data from 700 teachers from the public school system of a Brazilian municipality. The outcome of interest was DS, as assessed using the Beck Depression Inventory (BDI). Direct and indirect interrelationships between the outcome and dissatisfaction with work, age, income, lifestyle and adiposity were tested. These variables composed the operational model tested by structural equation modelling. Older age (β=0.12) and greater dissatisfaction with work (β=0.12) were directly associated with DS. A more favourable lifestyle (β=-0.60) and adiposity (β=-0.10) were associated with a lower occurrence of DS. The variables lifestyle (β=-0.06) and adiposity (β=-0.02) also had negative indirect effects on DS, mediated by job dissatisfaction. The structural equation model tested identified interrelationships that influenced DS. Dissatisfaction with teaching work was associated with DS and mediated the relationship of other factors with such symptoms.

Voice Disorders and Mental health of Basic Education Teachers in a Brazilian Municipality.

OBJECTIVE: To identify associations with voice disorders in elementary school teachers of a Brazilian municipality STUDY DESIGN: This was a quantitative cross-sectional and analytical study with probability sampling carried out in the 2016 school year METHOD: Self-report of vocal complaints was used for the dependent variable vocal disorder. The independent variables were sociodemographic and occupational characteristics, working conditions that generate discomfort, habits and behaviors, mental health and self-perception of health. For the evaluation of the Burnout Syndrome (BS), the questionnaire Cuestionário para la Evaluación del Syndrome de Quemarse por el Trabajo (CESQT) was used and, for depression, the Beck Depression Inventory (BDI) scale instrument. Multiple fit models were used applying the Binary Logistic Regression RESULTS: A total of 634 teachers participated in this study. There was a predominance of women (85.3%) with mean age 40.6 years (SD ±9.5); 62.1% were married, 70.2% had children and a mean teaching time of 12.9 years (SD ±8.4); 19.3% had voice disorders; 14.5% experienced BS and 24.0% depression. Voice disorders were associated with women (OR=2.30) working longer weekly hours (OR=1.75), with psycho-emotional problems, with burnout (OR=1.95) and depressive symptoms (OR=1.70), and were also associated with women who reported negative self-perception of health (OR= 1.97) CONCLUSION: Voice disorders appear to be strongly associated with mental health problems, mainly in women, in those with a longer working week and those who reported a negative perception of health. Public policies are required to prevent psycho-emotional problems and for vocal health promotion of the teaching category.

NEOTROPICAL FRESHWATER FISHES: A dataset of occurrence and abundance of freshwater fishes in the Neotropics.

The Neotropical region hosts 4225 freshwater fish species, ranking first among the world's most diverse regions for freshwater fishes. Our NEOTROPICAL FRESHWATER FISHES data set is the first to produce a large-scale Neotropical freshwater fish inventory, covering the entire Neotropical region from Mexico and the Caribbean in the north to the southern limits in Argentina, Paraguay, Chile, and Uruguay. We compiled 185,787 distribution records, with unique georeferenced coordinates, for the 4225 species, represented by occurrence and abundance data. The number of species for the most numerous orders are as follows: Characiformes (1289), Siluriformes (1384), Cichliformes (354), Cyprinodontiformes (245), and Gymnotiformes (135). The most recorded species was the characid Astyanax fasciatus (4696 records). We registered 116,802 distribution records for native species, compared to 1802 distribution records for nonnative species. The main aim of the NEOTROPICAL FRESHWATER FISHES data set was to make these occurrence and abundance data accessible for international researchers to develop ecological and macroecological studies, from local to regional scales, with focal fish species, families, or orders. We anticipate that the NEOTROPICAL FRESHWATER FISHES data set will be valuable for studies on a wide range of ecological processes, such as trophic cascades, fishery pressure, the effects of habitat loss and fragmentation, and the impacts of species invasion and climate change. There are no copyright restrictions on the data, and please cite this data paper when using the data in publications.

Dificuldades no ensino remoto emergencial da rede pública estadual de Minas Gerais no período pandêmico / Difficulties in emergency remote of the state public network of Minas Gerais in the pandemic period / Dificultades en la emergencia remota de la red pública es- tatal de Minas Gerais en el periodo pandémico

Este estudo objetivou-se analisar as dificuldades encontradas no ensino remoto emergencial (ERE) pelos professores da rede pública estadual de Minas Gerais durante o período pandêmico da COVID-19. Trata-se de estudo transversal com coleta realizada entre agosto e setembro de 2020, tipo websurvey. Utilizou-se a dificuldade encontrada com o ERE como variável dependente e as independentes foram características sociodemográficas e econômicas, perfil ocupacional, recursos/materiais e processos do trabalho docente. Participaram do estudo 15.641 professores. Observou-se prevalência de 90,6% de dificuldades no ERE. Os resultados, obtidos por meio da análise de Regressão de Poisson (α = 5%), apontaram associações entre o ERE e os professores do sexo feminino, a falta de recursos/materiais, o acesso limitado à internet e o processo de trabalho docente deficiente. Evidenciou-se um conjunto complexo de dificuldades que exige adequação de políticas públicas ao novo cenário educacional durante e pós- pandemia.

The objective was to analyse the difficulties encountered in emergency remote teaching (ERE) by teachers from the state public network of Minas Gerais during the COVID-19 pandemic period. This is a cross-sectional study with data collected be- tween August and September 2020, web survey type. The difficulty found with the ERE was used as a dependent variable, and the independent variables were sociodemographic and economic characteristics, occupational profile, resources/materials, and teaching work processes. 15,641 teachers participated in the study. There was a prevalence of 90.6% of difficulties in the ERE. The results, obtained through the Poisson Regression analysis (α=5%), indicated associations with the ERE of female teachers, the lack of re- sources/materials, limited access to the internet and the poor teaching work process. A complex set of difficulties was evidenced, which requires the adequacy of public policies to the new educational scenario during and after the pandemic.

El objetivo fue analizar las dificultades encontradas en la enseñanza remota de emergencia (ERE) por docentes de la red pública estatal de Minas Gerais durante el período pandémico del COVID-19. Se trata de un estudio transversal con datos entre agosto y septiembre de 2020, tipo encuesta web. Se utilizó como variable dependiente la dificultad encontrada con el ERE, y las variables independientes fueron características sociodemográficas y económicas, perfil ocupacional, recursos / materiales y procesos de trabajo docente. 15.641 profesores participaron en el estudio. Hubo una prevalencia del 90,6% de dificultades en el ERE. El análisis de regresión de Poisson (α = 5%) indicó asociaciones con el ERE de las maestras, falta de recursos / materiales, acceso limitado a Internet y un proceso de trabajo docente deficiente. Se evidenció un conjunto complejo de dificultades, que requiere la adecuación de las políticas públicas al nuevo escenario educativo durante y después de la pandemia.

Fatores de risco e proteção para doenças crônicas não transmissíveis entre professores da educação básica / Risk and protective factors for noncommunicable chronic diseases among primary education teachers

Resumo Objetivo: descrever as prevalências de fatores de risco e de proteção para doenças crônicas não transmissíveis (DCNT) e testar associações desses fatores com sexo, idade e satisfação com o trabalho entre professores da educação básica. Métodos: estudo transversal analítico realizado em Montes Claros, MG, Brasil, em 2016. Amostra probabilística por conglomerados. Utilizou-se questionário autoaplicável e avaliações físicas. Estimaram-se razões de prevalências (RP) e intervalos de confiança de 95% (IC95%) pela Regressão de Poisson. Resultados: dos 745 participantes, 83% eram mulheres, 81% tinham até 49 anos e 60% estavam insatisfeitos com o trabalho. Houve maior prevalência de fumantes entre homens (RP: 2,33; IC95%: 1,13;4,81), bem como consumo abusivo de álcool (RP: 7,24; IC95%: 2,19;23,91), excesso de peso (RP:1,48; IC95%: 1,04;2,13), menor prevalência de sintomas depressivos (RP:0,93; IC95%: 0,88;0,98) e de estresse (RP:0,88; IC95%: 0,82;0,95). Professores mais velhos apresentaram menor prevalência de Burnout (RP:0,87; IC95%: 0,81;0,94) e maior prevalência de comportamentos de proteção, apesar de terem maior comprometimento da saúde física. Professores insatisfeitos apresentaram maior prevalência de sintomas depressivos (RP:2,52; IC95%: 1,61;3,93), estresse (RP:1,76; IC95%: 1,33;2,32) e Burnout (RP:9,20; IC95%: 4,46;18,99). Conclusões: tabagismo, etilismo, excesso de peso e comprometimento da saúde mental foram fatores de risco frequentes para DCNT entre professores. Observaram-se diferenças nas prevalências de fatores de risco e de proteção para DCNT segundo sexo, idade e satisfação com o trabalho.

Abstract Objective: to describe the prevalence of risk and protective factors for noncomunicable chronic diseases (NCD) and test the association of these factors with sex, age, and job satisfaction among public primary and secondary schools teachers. Methods: analytical cross-sectional study in Montes Claros, MG, Brazil, carried out in 2016. We applied the probability cluster sampling technique. We used a self-applicable questionnaire and physical evaluations. We estimated Prevalence ratios (PR) and 95% Confidence Intervals (95%CI) using Poisson's regression. Results: of the 745 participants, 83% were women, 81% were 49 years old or younger, and 60% were unsatisfied with work. Smoking was more prevalent among men (PR: 2.33; 95%CI: 1.13;4.81), as well as alcohol abuse (PR: 7.24; 95%CI: 2.19;23.91), overweight (PR:1.48; 95%CI: 1.04;2.13), lower prevalence of depressive symptoms (PR: 0.93; 95%CI: 0.88;0.98) and stress (PR: 0.88; 95%CI: 0.82;0.95). Older teachers had a lower prevalence of burnout (PR: 0.87; 95%CI: 0.81;0.94) and a higher prevalence of protective behaviors, despite having a greater impairment of physical health. Unsatisfied teachers showed higher prevalence of depressive symptoms (PR: 2.52; 95%CI: 1.61;3.93), stress (PR: 1.76; 95%CI: 1.33;2.32), and burnout (PR: 9.20; 95%CI: 4.46;18.99). Conclusions: smoking, alcoholism, overweight, and mental health impairment were frequent risk factors for NCD among teachers. Differences were observed in the prevalence of risk and protection factors for NCD according to sex, age, and job satisfaction.

Factors associated with the lifestyle of state basic education teachers of state during the pandemic / Factores asociados al estilo de vida de los docentes de educación básica estatal durante la pandemia / Fatores associados ao estilo de vida dos professores da educação básica estadual na pandemia

ABSTRACT Objective: To analyze the prevalence and factors associated with the lifestyle profile of public basic education teachers in Minas Gerais during the COVID-19 pandemic. Method: Epidemiological websurvey carried out with public basic education teachers in Minas Gerais. Data collection took place from August to September2020 via digital form. Anthropometric, sociodemographic, work, and lifestyle characteristics were evaluated. Poisson Regression was used. Results: 15,641 teachers participated and 31.1% had inadequate health habits. There was a higher prevalence among men (PR=1.38; 95%CI:1.31;1.45), older age (PR=1.20; 95%CI: 1.07;1.34), greater weekly workload (RP=1.10; 95%CI:1.03;1.17) and those dissatisfied with work (RP=1.21; 95%CI:1.15;1.27). As a protective factor, professors with longer teaching experience (RP=0.92; 95%CI:0.87;0.98) and those hired or appointed (PR=0.89; 95%CI:0.85) ;0.94). Conclusion: Lifestyle inadequacy was found among older male teachers, with longer working hours and job dissatisfaction.

RESUMEN Objetivo: Analizar la prevalencia y los factores asociados al perfil de estilo de vida de los docentes de educación básica pública de Minas Gerais durante la pandemia de COVID-19. Método: Encuesta epidemiológica de tipo websurvey realizada con profesores de educación básica pública en Minas Gerais. La recolección de datos ocurrió de agosto a septiembre2020 a través de formulario digital. Se evaluaron características antropométricas, sociodemográficas, laborales y de estilo de vida. Se utilizó la Regresión de Poisson. Resultados: Participaron 15.641 docentes y el 31,1% presentaba hábitos de salud inadecuados. Hubo mayor prevalencia en hombres (RP=1,38; IC 95%: 1,31; 1,45), mayor edad (RP=1,20; IC 95%: 1,07; 1,34), mayor carga de trabajo semanal (RP=1,10; IC 95%: 1,03). ;1,17) y los insatisfechos con el trabajo (RP=1,21; IC95%:1,15;1,27). Como factor protector, profesores con mayor experiencia docente (RP=0,92; IC95%:0,87;0,98) y contratados o nombrados (RP=0,89; IC95%:0,85;0,94). Conclusión: Se encontró inadecuación en el estilo de vida entre los maestros hombres y mayores, con jornadas laborales más largas e insatisfacción laboral.

RESUMO Objetivo: Analisar a prevalência e fatores associados ao perfil do estilo de vida dos professores da educação básica pública de Minas Gerais na pandemia da COVID-19. Método: Inquérito epidemiológico websurvey realizado com professores da educação básica pública de Minas Gerais. A coleta de dados ocorreu de agosto a setembro/2020 via formulário digital. Foram avaliadas as características antropométricas, sociodemográficas, laborais e estilo de vida. Utilizou-se a Regressão de Poisson. Resultados: Participaram 15.641 professores e 31,1% apresentaram hábitos inadequados de saúde. Houve maior prevalência entre homens (RP=1,38; IC95%:1,31;1,45), maior idade (RP=1,20; IC95%: 1,07;1,34), maior carga semanal de trabalho (RP=1,10; IC95%:1,03;1,17) e os insatisfeitos com o trabalho (RP=1,21; IC95%:1,15;1,27). Como fator de proteção encontraram-se os professores com mais tempo de trabalho docente (RP=0,92; IC95%:0,87;0,98) e contratados ou designados (RP=0,89; IC95%:0,85;0,94). Conclusão: Verificou-se inadequação do estilo de vida entre os professores homens mais velhos, com maior jornada laboral e insatisfação com o trabalho.

A Betulinic Acid Derivative, BA5, Induces G0/G1 Cell Arrest, Apoptosis Like-Death, and Morphological Alterations in Leishmania sp.

Leishmaniasis are endemic diseases caused by different species of intracellular parasites of the genus Leishmania. Due to the high toxicity and drug resistance of current antileishmanial drugs, it is necessary to identify new and more effective drugs. Previously, we investigated the immunomodulatory and anti-Trypanosoma cruzi action of BA5, a derivative of betulinic acid. In the present study, we investigated the in vitro activity of BA5 against different species of Leishmania and their action mechanism. BA5 exhibited low cytotoxicity against macrophages and inhibited the proliferation of promastigote forms of Leishmania amazonensis (IC50 = 4.5 ± 1.1 µM), Leishmania major (IC50 = 3.0 ± 0.8 µM), Leishmania braziliensis (IC50 = 0.9 ± 1.1 µM) and Leishmania infantum (IC50 = 0.15 ± 0.05 µM). Incubation with BA5 reduced the percentage of Leishmania amazonensis-infected macrophages and the number of intracellular parasites (IC50 = 4.1 ± 0.7 µM). To understand the mechanism of action underlying BA5 antileishmanial activity (incubation at IC50/2, IC50 or 2xIC50 values of the drug), we investigated ultrastructural changes by scanning electron microscopy and evaluated cell cycle, membrane mitochondrial potential, and cell death against promastigote forms of Leishmania amazonensis by flow cytometry. Promastigotes incubated with BA5 presented membrane blebbing, flagella damage, increased size, and body deformation. Flow cytometry analysis showed that parasite death is mainly caused by apoptosis-like death, arrested cell cycle in G0/G1 phase and did not alter the membrane mitochondrial potential of Leishmania amazonensis. Surprisingly, the combination of BA5 and amphotericin B, an assay used to determine the degree of drug interaction, revealed synergistic effects (CI = 0.15 ± 0.09) on promastigotes forms of Leishmania amazonensis. In conclusion, BA5 compound is an effective and selective antileishmanial agent.

Impact of achondroplasia on Latin American patients: a systematic review and meta-analysis of observational studies.

BACKGROUND: Achondroplasia (ACH), the most common form of disproportionate short stature, is caused by a pathogenic variant in the fibroblast growth factor receptor 3 gene. Recent advances in drug therapy for ACH have highlighted the importance of elucidating the natural history and socioeconomic burden of this condition. Recognition that there are many potential issues for the patient with ACH is the first step in planning cost-effective interventions in Latin America (LATAM), a vast geographic territory comprising countries with multicultural characteristics and wide socioeconomic differences. We conducted a systematic literature review to characterize the impact of ACH on affected individuals and on healthcare resources in LATAM countries. METHODS: Searches of the global medical literature as well as regional and local medical literature up to August 2020. Observational studies on patients with ACH from any LATAM country. Pairs of reviewers independently screened eligible articles, extracted data from included studies, and assessed their risk of bias. RESULTS: Fifty-three unique studies (28 case series and cross-sectional studies and 25 case reports) including data on 1604 patients were eligible. Of these studies, 11 had data available for meta-analysis. Both premature mortality and all-cause mortality in the pooled studies was 15% [95% Confidence Interval (CI) 1.0E-3 to 0.47; I2 = 82.9%, p = 0.0029; three studies, n = 99 patients]. Frequency of cardio-respiratory-metabolic disorders was 17% [95% CI 0.04-0.37; I2 = 90.3%, p < 0.0001; four studies, n = 230 patients]; nervous system disorders was 18% [95% CI 0.07-0.33; I2 = 84.6%, p < 0.0001; six studies, n = 262 patients]; ear, nose, throat and speech disorders was 32% [95% CI 0.18-0.48; I2 = 73.4%, p = 0.0046; five studies, n = 183 patients]; and spinal issues including stenosis, compression and associated pain was 24% [95% CI 0.07-0.47; I2 = 91.3%, p < 0.0001; five studies, n = 235 patients]. CONCLUSIONS: There is currently evidence of high clinical burden in ACH patients in LATAM countries. Establishing the impact of ACH provides the necessary foundation for planning tailored and effective public health interventions.

Fatores associados à autoavaliação negativa de saúde entre professores da educação básica / Factors associated with negative self-assessed health among school teachers / Factores asociados con la autoevaluación negativa de la salud de los profesores de educación básica

A autoavaliação da saúde tem sido utilizada como ferramenta de medida da saúde de indivíduos e grupos populacionais, especialmente por sua relativa facilidade de aplicação. Buscou-se investigar a prevalência e os fatores associados à autoavaliação negativa de saúde entre professores da educação básica. Elaborou-se um estudo transversal, conduzido em uma amostra probabilística de professores em atividade em escolas estaduais de um município de médio porte do Sudeste brasileiro. A variável dependente foi obtida por meio da questão: "como você classificaria seu estado de saúde atualmente?". As opções de respostas foram agrupadas em autoavaliação positiva (excelente e bom) e negativa (regular, ruim e muito ruim). A análise dos dados foi realizada por meio da regressão de Poisson com variância robusta, em modelos bivariados e multivariados. A prevalência de autoavaliação negativa de saúde foi de 32,9% (IC 95%=28,8-37,4). No modelo final ajustado, permaneceram associadas à autoavaliação negativa da saúde: superlotação das turmas, insatisfação com o trabalho, sedentarismo, obesidade, relatos de doenças crônicas e de uma ou mais queixas vocais. Os resultados indicam a necessidade de intervenções tanto individuais, por meio de programas de promoção da saúde dos professores, quanto organizacionais, que visem a proteção da saúde dessa categoria profissional.

Self-assessment of health has been used as a measuring tool by individuals and population groups, especially for its relative ease of application. This study sought to investigate the prevalence of negative self-assessed health and associated factors among schoolteachers. A cross-sectional research was conducted with a probabilistic sample of state schoolteachers from a medium-sized municipality in southeastern Brazil. Response variable was collected via the question "How would you rate your current health status?", and the response options were grouped into positive (excellent, good) and negative (regular, bad, very bad) self-assessment. Data analysis was performed using Poisson's regression with robust variance, in bivariate and multivariate models. Negative self-assessed health showed a prevalence of 32.9% (95% CI = 28.8-37.4). After adjustment, overcrowded classes, job dissatisfaction, physical inactivity, obesity, reports of chronic illnesses, and at least one vocal complaint remained factors associated with negative self-assessment. Results indicate the need for both individual interventions, such as teacher health promotion programs, and organizational improvements to protect the health of schoolteachers.

La autoevaluación de la salud se ha utilizado como una herramienta de medida de la salud de individuos y grupos de población, especialmente por su relativa facilidad de aplicación. Se pretendió investigar la prevalencia y los factores asociados a la autoevaluación negativa de la salud entre los profesores de educación básica. Este es un estudio transversal realizado sobre una muestra probabilística de profesores que laboran en escuelas públicas de un municipio de tamaño mediano del Sudeste de Brasil. Las respuestas se obtuvieron basadas en la pregunta: "¿Cómo calificaría su estado de salud hoy?". Las opciones de respuesta se agruparon en autoevaluación positiva (excelente, buena) y negativa (regular, mala, muy mala). El análisis de los datos se realizó mediante regresión de Poisson con varianza robusta, en modelos bivariados y multivariados. La prevalencia de autoevaluación negativa de la salud fue del 32,9% (IC 95%=28,8-37,4). En el modelo final ajustado, los siguientes ítems permanecieron asociados con una autoevaluación negativa de la salud: hacinamiento de clases, insatisfacción laboral, inactividad física, obesidad, informes de enfermedades crónicas y una o más quejas vocales. Los resultados indican la necesidad de intervenciones tanto individuales, por medio de programas de promoción de la salud docente, como organizacionales, dirigidas a proteger la salud de esta categoría profesional.

Working conditions, lifestyle and mental health of Brazilian public-school teachers during the COVID-19 pandemic.

This study aimed to describe the working conditions, lifestyle and mental health of Brazilian public-school teachers during the COVID-19 pandemic. This is an epidemiological websurvey, carried out from August to September 2020. Teachers from public schools in rural and urban areas in the state of Minas Gerais, Brazil, participated in the study. A digital questionnaire was used and the study addressed variables related to four major thematic topics: sociodemographic and economic profile, working conditions, lifestyle and health conditions, and mental health problems during the pandemic. The sample consisted of 15,641 teachers, of which 13.3% worked in rural areas, 81.9% were women, 56.2% were aged 41-60 years, 66.8% were married, 99.2% were working remotely and 79.8% adhered to social distancing. During the pandemic, 40.6% showed a decrease in family income, 33.7% were dissatisfied with their work, 58% reported increased body weight, 47.9% did not exercise, 35.8% were part of at least one risk group for COVID-19, 40.5% had some flu-like symptoms during the pandemic and 1.2% tested positive for COVID-19. Regarding mental health problems, 25.9% of teachers self-reported formal diagnosis of anxiety and/or depression during the pandemic. In addition, 7.1% of teachers were drinking more alcohol than usual, 33.4% started having sleep problems, 30.4% were using relax/sleep/anxiety/depression medications, 67.1% reported that their quality of life worsened and 43.7% reported having severe fear of COVID-19. It was also found that 82.3% of teachers had at least one mental health problem during the pandemic, such as increased alcohol consumption, sleep problems, use of psychotropic medication, decreased quality of life, and fear of COVID-19. The results of this study reveal the numerous challenges and the extent of the impact of the pandemic on working conditions, lifestyle, and especially on the mental health of teachers.

Fatores associados à ocorrência de infecção e internação por COVID- 19 em professores de Minas Gerais em 2020 / Factors associated with the occurrence of infection and hospitalization due to COVID-19 in teachers from Minas Gerais, 2020

O objetivo do estudo foi identificar fatores associados à ocorrência de infecção confirmada e internação por COVID- 19 entre professores da educação pública de Minas Gerais. Estudo transversal realizado entre agosto e setembro de 2020, via internet. As variáveis dependentes foram relatos de teste positivo para COVID-19 e ocorrência de internação. Realizou-se Regressão de Poisson. Participaram 15.641 professores. A prevalência de infecção por COVID-19 foi de 1,2%; e foi maior entre as mulheres (RP: 1,69; IC 95%: 1,08;2,66), aqueles com renda de 10 salários ou mais (RP: 2,83; IC95%: 1,40;5,75), plano privado de saúde (RP: 1,52; IC95%: 1,09;2,11), que não receberam informações sobre a COVID-19 (RP: 2,06; IC95%: 1,19;3,58), obesos (RP: 1,55; IC 95%: 1,11;2,17) e cujo amigo ou familiar desenvolveu sintomas graves da COVID-19 (RP: 3,13; IC95%: 2,31;4,24). Entre os infectados, 6,5% foram internados, houve maior prevalência entre grupos de risco da COVID-19 (RP: 1,11; IC95%: 1,02;1,20). Concluindo, a ocorrência da infecção relacionou-se às questões sociodemográficas, acesso a informações, saúde e contatos prévios. Já a internação foi mais prevalente nos considerados grupos de risco para a COVID-19.

The aim of the study was to identify factors associated with the occurrence of confirmed infection and hospitalization due to COVID-19 among public education teachers in Minas Gerais. Cross-sectional study carried out between August and September 2020, via internet. The dependent variables were report of a positive tests for COVID-19 and the occurrence of hospitalization. Poisson Regression was performed. 15,641 teachers participated. The prevalence of infection for COVID-19 was 1.2%, and was higher among women (PR: 1.69, CI 95%: 1.08;2.66), with income of 10 salaries or more (PR: 2.83, CI95%: 1.40;5.75), private health insurance (PR: 1.52, CI95%: 1.09;2.11), who did not receive information about COVID-19 (PR: 2.06, CI95%: 1.19;3.58), obese (PR: 1.55; CI 95%: 1.11;2.17) and whose friend or family member developed severe symptoms of COVID-19 (PR: 3.13, CI95%: 2.31;4.24). Among those infected, 6.5% were hospitalized, there was a higher prevalence among risk groups for COVID-19 (PR: 1.11, CI95%: 1.02;1.20). In conclusion, the occurrence of the infection was related to sociodemographic issues, access to information, health and previous contacts. Hospitalization was more prevalent in groups considered at risk for COVID-19.

Structural Design, Synthesis and Antioxidant, Antileishmania, Anti-Inflammatory and Anticancer Activities of a Novel Quercetin Acetylated Derivative.

Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water, extensive enzymatic metabolism and a reduced bioavailability limit its biopharmacological use. The aim of this study was to perform structural modification in Q by acetylation, thus, obtaining the quercetin pentaacetate (Q5) analogue, in order to investigate the biological potentials (antioxidant, antileishmania, anti-inflammatory and cytotoxicity activities) in cell cultures. Q5 was characterized by FTIR, 1H and 13C NMR spectra. The antioxidant potential was evaluated against the radical ABTS•+. The anti-inflammatory potential was evaluated by measuring the pro-inflammatory cytokine tumor necrosis factor (TNF) and the production of nitric oxide (NO) in peritoneal macrophages from BALB/c mice. Cytotoxicity tests were performed using the AlamarBlue method in cancer cells HepG2 (human hepatocarcinoma), HL-60 (promyelocytic leukemia) and MCR-5 (healthy human lung fibroblasts) as well as the MTT method for C6 cell cultures (rat glioma). Q and Q5 showed antioxidant activity of 29% and 18%, respectively, which is justified by the replacement of hydroxyls by acetyl groups. Q and Q5 showed concentration-dependent reductions in NO and TNF production (p < 0.05); Q and Q5 showed higher activity at concentrations > 40µM when compared to dexamethasone (20 µM). For the HL-60 lineage, Q5 demonstrated selectivity, inducing death in cancer cells, when compared to the healthy cell line MRC-5 (IC50 > 80 µM). Finally, the cytotoxic superiority of Q5 was verified (IC50 = 11 µM), which, at 50 µM for 24 h, induced changes in the morphology of C6 glioma cells characterized by a round body shape (not yet reported in the literature). The analogue Q5 had potential biological effects and may be promising for further investigations against other cell cultures, particularly neural ones.

Checklist of decapod crustaceans from the coast of the São Paulo state (Brazil) supported by integrative molecular and morphological data: IV. Infraorder Anomura: Superfamilies Chirostyloidea, Galatheoidea, Hippoidea and Paguroidea.

This checklist is the fourth contribution resulting from a long-term multidisciplinary project which combined morphological analyses and molecular techniques (mitochondrial DNA markers) for accurate identification of marine and coastal decapod crustaceans of São Paulo State (Brazil). We provide a list of 63 species of the following 11 families of 4 superfamilies of Anomura: Albuneidae (4 spp.), Blepharipodidae (1 sp.), Chirostylidae (1 sp.), Diogenidae (18 spp.), Hippidae (1 sp.), Munididae (8 spp.), Munidopsidae (1 sp.), Paguridae (13 spp.), Parapaguridae (2 spp.), Porcellanidae (13 spp.), and Pylochelidae (1 sp.). Seven species previously reported from the region were neither collected nor found in museum collections during our study, including one (Sympagurus dimorphus) that we suggest to be removed from São Paulo coast fauna lists. We generated new sequences of cytochrome oxidase subunit I (barcode region) and 16S genes of 44 species. This anomuran inventory may serve as guideline for future studies on taxonomy, conservation, population genetics, biogeography, and phylogenetics, which might flag species that deserve further investigations and concerns.

Prevalence of overweight/obesity and associated factors among basic education teachers in a city in the north of Minas Gerais, Brazil / Prevalência de sobrepeso/obesidade e fatores associados em professores da educação básica de um município do norte de Minas Gerais, Brasil

ABSTRACT Objective To estimate the prevalence of overweight/obesity and its associated factors among basic education teachers. Methods This is a cross-sectional study with probabilistic sampling by clustering. A questionnaire with socio-demographic, occupational, and psychosocial variables, as well as lifestyle, and health profiles was used. Results 707 teachers participated in the study. Associations with overweight / obesity were found for the variables: the male gender, age >40 years, three or more children, workload, contracted/designated employment relationship, fat intake through meat, abusive consumption of alcoholic beverages, presence of depressive episodes, endocrine problems, arterial hypertension, and negative self-perception of health with the prevalence ratio ranging from 1.16 to 1.52 in the associated variables. Conclusion Overweight / obesity affected approximately half of those surveyed. There is a relationship between sociodemographic, occupational, and psychosocial variables and lifestyles, on the one hand, and health factors and the presence of overweight / obesity in teachers, on the other. Measures must be implemented on modifiable factors, aiming to promote their quality of life.

RESUMO Objetivo Estimar a prevalência e os fatores associados ao sobrepeso/obesidade entre professores da Educação Básica. Métodos Trata-se de um estudo transversal com amostragem probabilística por conglomerado. Utilizou-se questionário com variáveis sociodemográficas, ocupacionais, psicossociais, estilo de vida e perfil de saúde. Resultados Participaram do estudo 707 professores. Verificaram-se associações com sobrepeso/obesidade nas variáveis: sexo masculino, idade >40 anos, três ou mais filhos, carga horária de trabalho, vínculo empregatício contratado/designado, consumo de gordura através da ingestão de carnes, consumo abusivo de bebidas alcoólicas, presença de episódios depressivos, problemas endócrinos, hipertensão arterial e autopercepção negativa da saúde com razão de prevalência variando entre 1,16 a 1,52 entre as variáveis associadas. Conclusão O sobrepeso/obesidade acometeu, aproximadamente, metade dos pesquisados. Há uma relação entre os fatores sociodemográficos, ocupacionais, do estilo de vida, psicossociais e de saúde e a presença de sobrepeso/obesidade em professores. Medidas devem ser implementadas sobre os fatores modificáveis, com vistas a promoção da sua qualidade de vida.

Prevalência e fatores associados à síndrome de burnout entre docentes da rede pública de ensino: estudo de base populacional / Prevalence and associated factors of burnout syndrome among teachers of the public network: a population-based study

Resumo Objetivos: identificar a prevalência e os fatores associados à síndrome de burnout (SB) entre docentes da educação básica de escolas públicas de um município de médio porte. Métodos: estudo transversal analítico realizado em Minas Gerais, em 2016. Coletaram-se dados sociodemográficos e ocupacionais e aplicou-se o Cuestionário para la Evaluación del Síndrome de Quemarse por el Trabajo para avaliar a SB. A amostra (n = 745) foi probabilística por conglomerados em único estágio. Utilizou-se análise hierarquizada com regressão de Poisson. Resultados: a prevalência geral da SB foi de 13,8% (IC95%: 11,3-16,3%), com 9,0% apresentando o Perfil 1 (SB sem níveis altos de sentimento de culpa) e 4,8% o Perfil 2 (SB grave). As dimensões mais prevalentes foram "desgaste psíquico" (39,4%) e "ilusão pelo trabalho" (19,7%). A prevalência de SB foi maior entre os docentes mais jovens (RP = 1,82), sem filhos (RP = 1,45), concursados/efetivos (RP = 1,88), insatisfeitos no trabalho (RP = 3,16), com desejo de mudar de profissão (RP = 2,94) e com falta de apoio da direção escolar (RP = 2,38). Conclusão: há urgência na criação de políticas públicas de suporte aos docentes, pois os identificados com sintomas da síndrome estão em exercício funcional, o que agrava seu quadro de saúde e, por conseguinte, compromete os diversos processos da área educacional.

Abstract Objectives: to identify the associated factors and the prevalence of burnout syndrome (BS) in primary and secondary public school teachers of a medium-sized municipality. Methods: cross-sectional analytical study conducted in Minas Gerais, Brazil, in 2016. We collected sociodemographic and occupational data, and applied the Spanish Burnout Inventory [Cuestionário para la Evaluación del Síndrome de Quemarse por el Trabajo]. The sample (n = 745) was probabilistic by clusters in a single stage. We used Hierarchical analysis with Poisson regression. Results: the general prevalence of BS was 13.8% (95% CI: 11.3-16.3%), with 9.0% having Profile 1 (BS without high levels of feelings of guilt) and 4.8% Profile 2 (severe BS). The most prevalent dimensions were "psychological exhaustion" (39.4%) and "enthusiasm towards job" (19.7%). The BS prevalence was higher among younger teachers (PR = 1.82), without children (PR = 1.45), job stability insured as civil servant (PR = 1.88), with job dissatisfaction (PR = 3.16), with a desire to change professions (PR = 2.94) and lack of support from the school managers (PR = 2.38). Conclusion: there is an urgent need to develop public policies to support teachers, since those identified with BS symptoms are in work activity, which worsens their health condition and, therefore, undermines the educational processes.

Checklist of decapod crustaceans from the coast of the São Paulo state (Brazil) supported by integrative molecular and morphological data: III. Infraorder Brachyura Latreille, 1802.

This checklist is the third part of a series derived from a long-term multidisciplinary project on the biodiversity of decapod crustaceans from marine and coastal environments of São Paulo state (Brazil). We integrated molecular techniques (DNA markers) and morphological analyses of adult specimens for accurate identifications. We compilated 185 species from the literature, but we confirmed the presence of 168 species: 130 of which we sampled, analyzed and obtained sequences (COI and/or 16S totalizing 113 sequences) and 38 that were not directly collected but were confirmed by analyses. In addition, 27 had their distribution removed from São Paulo due to uncertainties, and absence of material as voucher. Five species were reported for the first time on the coast of São Paulo (Calappa ocellata, Neohelice granulata, Teleophrys pococki, Teramnonotus monodi, Tetraxanthus rathbunae) and one on the Brazilian coast (Pseudomedaeus agassizi). Most of the non-sampled species previously reported on the coast of São Paulo might be considered doubtful records stablished in the past by inaccurate analyses, which assumed extended distribution to the area and/or misidentifications. At this time and based on our refined compilation, we can estimate the brachyuran diversity on the coast of São Paulo in 168 species. This detailed inventory contributes to the knowledge on the local decapod fauna by checking available dataset, adding new species records in São Paulo and new sequences to GenBank database. These data may serve as baseline for future identifications and studies on conservation, population genetics, biogeography and phylogenetics, which might flag species that deserve further investigations and concerns.

[Arterial Hypertension and work among teachers of basic education in the public-school system]. / Hipertensão Arterial e trabalho entre docentes da educação básica da rede pública de ensino.

The scope of this paper was to investigate the relationship between Arterial Hypertension (AH) and the occupational profile of teachers of basic public education and present a theoretical model. A probabilistic sample was adopted by clusters, with AH as the dependent variable. The independent variables were grouped in thematic blocks (Sociodemographic Characteristics, Occupational Profile, Behaviors and Health Outcomes) that composed the theoretical model. The analyses were corrected by the sample design. Hierarchical logistic regression was conducted. The prevalence of AH was 25%, and 58% reported dissatisfaction with the work. There was a higher probability of AH among older teachers (OR = 3.7), without postgraduate qualification (OR = 1.4), who also worked in the private network (OR = 2.6), who had a higher salt intake (OR = 1.7), with a high waist-hip ratio (OR = 1.9) and hypercholesterolemia / hypertriglyceridemia (OR = 1, 5) and a lower chance among females (OR = 0.5), who had other work activity (OR = 0.6) and were dissatisfied with the work (OR = 0.6). Thus, the occupational profile of teachers had an influence on AH. The relationship between work and teacher health demands attention and care, with measures that preserve and promote the health and well-being of teachers.

Objetivou-se investigar a relação entre Hipertensão Arterial (HA) e perfil ocupacional de docentes da educação básica pública e apresentar modelo teórico. Adotou-se amostra probabilística por conglomerados. A HA foi a variável dependente. As variáveis independentes foram agrupadas em blocos temáticos (Características Sociodemográficas, Perfil Ocupacional, Comportamentos e Desfechos em Saúde), que compuseram o modelo teórico. As análises foram corrigidas pelo desenho amostral. Foi conduzida regressão logística hierarquizada. A prevalência de HA foi de 25%, enquanto que 58% apresentaram insatisfação com o trabalho. Houve maior chance de HA entre os docentes mais velhos (OR = 3,7), sem pós-graduação (OR = 1,4), que atuavam também na rede privada (OR = 2,6), que apresentavam maior consumo de sal (OR = 1,7), com sobrepeso (OR = 2,1) / obesidade (OR = 7,2), com relação cintura-quadril elevada (OR = 1,9) e com hipercolesterolemia/hipertrigliceridemia (OR = 1,5) e menor chance entre os do sexo feminino (OR = 0,5), que exerciam outra atividade de trabalho (OR = 0,6) e insatisfeitos com o trabalho (OR = 0,6). Assim, o perfil ocupacional docente apresentou influência sobre a HA. A relação trabalho e saúde docente carece de atenção e cuidado, com adoção de medidas que preservem e promovam sua saúde e seu bem-estar.